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The regulatory effect of GPX8 on Ca 2+ may be related to the inositol 1,4,5-triphosphate receptor (IP3R) effect, and the transmembrane domain (TMD) of GPX8 is thought to play a key role in the regulation of Ca 2+ signaling (Yoboue et al., 2017)

In: Papageorgiou GC, Govindjee, editors

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The dose and duration of the intervention were determined according to the previous studies, which showed that AST in a daily dose of 2 to 24 mg exhibits antioxidant properties with no safety concerns and side effects after at least a 3-week intervention ( , Folsure 800, Germany