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The mutated p53 protein often loses its ability to regulate the G1/S and G2/M checkpoints, not only permitting tumor cells to continue proliferating under DNA damage or other stress conditions but also potentially promoting tumor growth and metastasis by activating other oncogenic pathways and altering the tumor microenvironment to enhance invasiveness and metastatic potential ( 2.2 Tumor microenvironment characteristics The mechanisms of drug resistance in HGSOC are complex and diverse, and recent studies have demonstrated a close association between its molecular characteristics and drug resistance

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10.1104/pp.103.029876 26 FranceschiniA.SzklarczykD.FrankildS.KuhnM.SimonovicM.RothA.et al