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Stingl et al noted that CYP2D6 IM phenotypes are carriers either of 1 normal allele + 1 nonfunctional allele (*1/def), 1 nonfunctional allele + 1 reduced-function allele (def/red), or 2 reduced function alleles (red/red)

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In a randomized multicenter trial (published in JAMA Dermatology in 2015), the combination of afamelanotide implants plus NB-UVB produced faster and more noticeable repigmentation than NB-UVB alone, with monitoring considerations

Animal studies show that BPC-157 administration produces antidepressant-like behavior alongside gastrointestinal healing, with the two effects appearing in parallel rather than sequentially