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Cette carence peut tre due diffrentes causes, comme la maladie de Biermer (pouvant tre li une problmatique au niveau de la paroi de lestomac, une carence du facteur intrinsque, ), une gastrectomie (retrait partiel ou total de lestomac), une infection Helicobacter Pylori, une insuffisance pancratique ou encore une maladie inflammatoire de l'intestin