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H2O2, which is not a radical but has high reactivity, also plays a significant role (87)

The genetic background variation and combinatorial effects of different factors in patient fibroblasts, which have expressed the mutant FUS/TLS for a long time, make it difficult to systematically correlate with the effects from acute loss of FUS/TLS or SMN protein

In particular, some studies report the ratio of free GSH to GSSG [19, 22,23,24,25,26], whereas others quantify and report total GSH (i.e., free GSH + 2xGSSG) [12, 19, 24, 26,27,28,29,30]