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Comparison of sulfur amino acid utilization for GSH synthesis between HepG2 cells and cultured rat hepatocytes

Curr Opin Neurobiol (2014) 29:18

Additionally, a streptozotocin (STZ)-induced type 1 diabetes rat model, which also results in reduced insulin through cell loss, was reported to have showed decreased endothelial ZO-1 and occludin and increased MMP activity in blood (Hawkins et al., 2007), suggesting changes in vascular permeability can be a direct consequence of high blood glucose

GSH forms adducts with its metabolite, bisphenol A-3,4-quinone (BPAQ), yielding two different products possessing one or two molecules of GSH [91,92]