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1 Introduction Osteoarthritis (OA) is among the most prevalent degenerative joint diseases globally, affecting more than 500 million people worldwide and ranking as the leading cause of disability among adults aged 50 years and older ( Ferroptosis, first reported in 2012, is a novel form of cell death distinct from classical apoptosis, pyroptosis, and necrosis ( Due to the possible critical role of ferroptosis in OA, there has been a surge of interest in elucidating its molecular mechanisms and exploring potential therapeutic strategies

Insulin syringes (0.3mL or 0.5mL) are the correct instrument for accurate Tirzepatide dose measurement due to their smaller capacity and finer unit graduation, ensuring the integrity of protocols for Tirz 20mg and similar strengths

In pancreatic regeneration, sEVs activate the PDX-1 signaling axis to promote -cell regeneration and insulin secretion (Mahdipour et al., 2019)

Hassen W, Abid S, Achour A, Creppy E, Bacha H