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These methods which rely upon in vitro translation, generally comprising stabilized polysome complexes, are described further in PCT patent publications WO 88/08453, WO 90/05785, WO 90/07003, WO 91/02076, WO 91/05058, and WO 92/02536

Luminal contents can pass across the epithelial barrier via transcellular passive, active or endocytosis mechanisms, or via paracellular pathway

Histone modification probably plays an essential role in the regulation of host anti-Mtb immunity, since inhibition of histone deacetylases (HDACs) in human monocytes leads to attenuated host immune clearance of Mtb

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