kb glutathione dosage per day Frontiers Targeting Metabolic Vulnerabilities Reveals Hexokinase

Across mice, rats, fruit flies, and primates, epithalamin/Epithalon treatment extended average lifespan by 1225% depending on the model [2]

Back Deacon, DF, Johnsen, AH, Holst, JJ (March 1995) 'Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo', Journal Clinical Endocrinology Metabolism , 80/3, 952-7

p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy

Using a redox-sensitive fluorescent reporter (Mrx1-roGFP2), flow cytometry, and transcriptomics, we found that macrophages with high oxidative phosphorylation (OXPHOS) and low glycolysis harbor reductive, drug-tolerant Mtb , whereas glycolytically active macrophages generate mitochondrial ROS via reverse electron transport, imposing oxidative stress on Mtb and enhancing drug efficacy