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The clinical evidence base for these agents, both individually and in combination, is still emerging

It directly impacts both measured outcomes and dropout rates due to nausea

Small-molecule TKIs include imatinib, dasatinib, nilotinib, ponatinib, bosutinib, sorafenib, sunitinib, pazopanib, axitinib, vandetanib, dovitinib, vemurafenib, dabrafenib, and ruxolitinib