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The most frequent AEs (2% in any treatment group) that occurred more often in the ritlecitinib groups than placebo and were dose-related included diarrhea, acne, urticaria, rash, and dizziness.21Table 2 lists AEs that occurred in 5% of patients in any treatment group within the all-exposure cohort.25 Adverse events of special interestInfections The incidence rate (IR) of serious infections was low across the ALLEGRO program

An association study of HFE gene mutation with idiopathic male infertility in the Chinese Han population

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SCD is characterized by intravascular hemolysis, driven by the polymerization of mutated hemoglobin within red blood cells (RBCs), leading to vascular inflammation, organ damage, and heme toxicity