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[DOI] [PMC free article] [PubMed] [Google Scholar] 69.Yang CL, Hicks EA, Mitchell P, Reisman J, Podgers D, Hayward KM, et al

doi: 10.1016/j.jep.2008.11.011

Retrieved 16 May 2021

Pushing through with a dose increase typically makes symptoms worse, not better, and can lead to treatment discontinuation, which defeats the entire purpose of the graduated approach