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Data of panels a, b are mean values standard deviation of three independent replicates

When that NNMT machine runs hot, especially in adipose tissue, it chews through SAM and eats into the raw material for NAD+

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2.2 Lactate shuttle Lactate, the terminal glycolytic metabolite, functions as a versatile molecular shuttleintracellularly, intercellularly, and systemicallymodulating cellular bioenergetics and redox equilibrium while accumulating across tissues via circulatory transport ( The aforementioned glycolytic reprogramming drives profound lactate and proton accumulation