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There are many potential causes of widespread tenderness. (69) The mottled clinical presentations of fibromyalgia overlap with a variety of concurrent or alternate disorders, including hypothyroidism, anemia, inflammatory arthropathy, Lyme disease, multiple sclerosis, occult malignancy, irritable bowel syndrome, celiac disease, chronic fatigue syndrome, migraine, myofascial pain syndrome, reaction to statins, hypermobility syndrome, parasitic diseases, and adult growth hormone deficiency syndrome

Interestingly, although p53 appears to act as this networks master regulator, it exists as a single copy

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