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Description

This activation increases the transcription of MAFbx and MuRF1, enhancing the proteolytic activity of the UPS

The steroid receptor RNA activator gene is an unusual gene that expresses two different transcripts by alternative splicing of the first intron: (1) the lncRNA SRA and (2) the SRAP protein gene (Hube et al., 2006)

Collectively, these data position commensal-derived EPS as candidate microbe-based therapeutics capable of restoring the Treg/Th17 balance and mitigating inflammation-facilitated stone formation