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For instance, oedematous SAM is associated with secondary immune deficiency, intestinal dysbiosis, epithelial barrier disruption, and growth faltering, all of which exacerbate inflammation and worsen immune dysfunction (appendix p

Furthermore, the inhibition of proteolytic enzymes was suggested to promote the activation of apoptotic events in MCF-7 breast cancer cells (228)

10.2147/IJN.S132163 31

Our research suggests that the defect of complement in multiple myeloma should not be explained on the basis of a single complement component abnormality, but rather results from a group of complement abnormalities