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Upon ischemic injury in stroke, neuronal HMGB1 is abundantly released into the extracellular space, both by active secretion and passive release, to accumulate in the ischemic core of the acute phase and to activate resident brain immune cells, leading to the recruitment of mononuclear cells that further amplify inflammation (Singh et al., 2016)

These findings highlight the potential of metabolic interventions to restore immune homeostasis through Treg modulation

36 In summary, the trajectory of orally administered single-stimulus responsive materials physical sterilization-enhancing materials multimodal theranostic platforms constitutes a rational, stepwise translational roadmap for the field of nanomaterial-mediated H

Blood glucose levels were measured every 15 to 60 minutes using an Infinity glucose meter (US Diagnostics)