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Patients were randomized (n=456) to receive ALIMTA 500 mg/m2 intravenously over 10 minutes followed 30 minutes later by cisplatin 75 mg/m2 intravenously over two hours on Day 1 of each 21-day cycle or to receive cisplatin 75 mg/m2 intravenously over 2 hours on Day 1 of each 21-day cycle

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It has been found that the dynamic changes in mitochondria and CR structure formed by endointimal folding have a significant impact on the integrity of mtDNA