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Lastly, while APOE effects dominated brain profiles, sex effects were more prominent in the periphery, which was also in accordance with a previous study in older (16 months old) APOE-TR mice (Shang et al., 2020), suggesting that regardless of age APOE has a major effect on brain bioenergetics

3), and increased expression level of Bax (Fig

Current evidence on KD and the skin remains limited, focusing mainly on inflammatory skin diseases such as acne, psoriasis, and hidradenitis suppurativa (HS), as well as cutaneous melanoma

The transfer of an acetyl group onto specific lysine residues results in a loss of positive charge on histones, thereby destabilizing the histone-DNA interaction, increasing chromatin accessibility for RNA polymerases and transcription factors, and enhancing translation