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HCAR1-mediated lactate effects have been suggested to be neuroprotective in depression (Tang et al., 2014

W., Zhang Q

Coron Artery Dis 26(2):176183 Rights and permissions About this article Cite this article Luft, F.C

Various factors, such as skin aging, inflammation, sunlight exposure, wound healing, and fibrosis, can promote ECM remodeling, potentially resulting in aberrant ECM modifications (Pfisterer et al, 2021), which may modify the presentation of ECM ligands and alter substrate stiffness