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By contrast, APEX2, also targeted to the cell surface, provided much weaker staining of the plasma membrane relative to intracellular organelles (Supplementary Fig

Wilk AJ, Rustagi A, Zhao NQ, Roque J, Martnez-Coln GJ, McKechnie JL, et al

The duration of use of each agent is unclear, with most studies evaluating the treatment of CIPN over periods ranging from 2 weeks to as much as 12 weeks