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Comparative Collagen Production Analysis 70% of women showed improved collagen production 50% of women showed improved collagen production 40% of women showed improved collagen production A randomized double-blind 8-week trial comparing GHK-Cu in nano-lipid carrier against Matrixyl 3000 demonstrated 55.8% reduction in wrinkle volume versus control serum and 31.6% reduction versus Matrixyl 3000, with 32.8% reduction in wrinkle depth versus control