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Glutathione metabolism modulates the sensitivity to BH3 mimetics Glutathione S-transferases (GST) are detoxifying enzymes that protect mammalian macromolecules from reactive electrophilic substances using glutathione (GSH) as a xenobiotic acceptor 49

By promoting mitochondrial function, it enhances the overall energy production process and supports better endurance

Also metoprolol reduced the plasma norepinephrine concentration in losartan-treated WKY and SHR ( P = NS compared to metoprolol alone, and P 0.013 compared to losartan alone)

Pre-clinical vs Clinical Translation Challenges Concentrations that produce robust in-vitro fibroblast responses may not translate predictably to in-vivo or human contexts