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doi:10.1016/j.bbagen.2012.10.012 Richie JP Jr, Nichenametla S, Neidig W, et al

10.1016/S0962-8924(98)01359-2 Trends Cell Biol

How Needle Degradation Affects Medication Delivery A dull needle requires additional force to penetrate skin, causing the injection to feel more painful and potentially traumatizing surrounding tissue