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Pr D, Franke SI, Henriques JA, Fenech M

They are not recognized as generally regarded as safe (GRAS) substances for dietary supplement use

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It does so through an epigenetic mechanism, where FGF15/19 interacts with its target nuclear receptors, such as small heterodimer partner (SHP), which then recruits DNA methyltransferase-3a (DNMT3a) to the lipogenic gene loci, including FASN