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This indicates the efficacy of using MET inhibitors alongside ICIs in treating tumors where MET is dysregulated and PD-L1 expression is elevated

2 O predominantly affect glutamatergic transmission by antagonizing NMDA receptors (NMDARs), causing excitotoxicity, mitochondrial dysfunction, and neuronal apoptosis

The combinational effects of N-terminal mutations and C-terminal affinity-enhancing mutations shown in this study remain to be tested for the future study