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It is driven by iron-dependent phospholipid peroxidation and regulated by several cellular metabolic events, including redox homeostasis, iron handling, mitochondrial activity, and metabolism of amino acids, lipids and sugars [67]

However, in some cases the immune reaction continues, leading to an excessive inflammatory response often referred to as a cytokine storm. In an effort to define some of the key players in SARS-CoV-2-associated cytokine storms, a group in France analyzed the cytokine responses in fifty COVID-19 patients experiencing varying disease severity

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The role of the anterior cingulate cortex in prediction error and signaling surprise