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HB reduces inflammation while increasing mitochondrial function HB serves several signaling functions in addition to its role as an ATP-generating metabolite (79)

10.1016/j.devcel.2015.09.008 51 DanaiL

Values presented as Least-squares mean (95% confidence interval [two numbers] or standard error [single number]) for continuous variables and as percentage of total for categorical variables Results represent changes from baseline to 48 weeks in the obesity trial, *excluding blood pressure which was change to 36 weeks

Additionally, it has been suggested that optimizing parameters, such as phospholipid composition, PEGylation, and liposome modification, can further promote drug bioavailability in brain tissues