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Inhibition of Schistosoma mansoni thioredoxin glutathione reductase by auranofin: Structural and kinetic aspects

In vitro studies of the hemoglobin auto-oxidation revealed that the reaction is slow ( k = 0.0115 h 1 ) under normoxic conditions (Nagababu et al., 2002), but is facilitated dramatically upon partial deoxygenation (Abugo and Rifkind, 1994) and is maximal at pO 2 of 1.33 kPa (Rifkind et al., 2004)

Any references to senescence, cellular aging, or regeneration are included strictly for literature indexing and experimental context

This is because heat, moisture, and light can all contribute to the degradation of the vitamin and reduce its effectiveness