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10.1016/j.lfs.2020.118375 174

The polyol pathway, where excess glucose is converted to sorbitol and fructose by the enzyme aldose reductase, further exacerbates oxidative stress by depleting NADPH, a crucial cofactor for the regeneration of reduced glutathione (GSH) [180]

10.1016/j.freeradbiomed.2017.03.011 86 LiY.ChenL.ZhengD.LiuJ

Patient 2 is a 35-year-old female with focal unaware seizures from right hemisphere with whole-cerebral spread status post long-term vagal nerve stimulator placement in 2013 (6 years prior to the current study) and no prior surgical intervention, currently on lamotrigine, carbamazepine, and topiramate