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The gained information has allowed to explain some phenomena observed in toxicological studies performed at the level of cell cultures and of isolated tissue and organ preparations, and to finally propose an explanation for the peculiar toxicological behavior ( i.e

Similar content being viewed by others Introduction Gout due to monosodium urate (MSU) crystal deposition, which occurs after chronic elevation of serum urate level, and calcium pyrophosphate (CPP) crystal deposition (also called chondrocalcinosis) are 2 major crystal-related diseases responsible for recurrent interleukin 1 (IL-1)-orchestrated inflammation flares

After incubation with trypsin, the peptide concentration in samples was estimated using a Micro BCA Protein Assay (Thermo Scientific, #23235), and a volume corresponding to 25 g peptides was transferred to a new low-bind Eppendorf tube per sample