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Conclusion Undereye dark circles are multifactorial, with both clinical and non-clinical elements contributing to their development

Non-shivering thermogenesis in both brown and beige adipocytes is dependent on the protein uncoupling protein 1 (UCP-1), which dissipates the proton gradient across the inner mitochondrial membrane thereby uncoupling respiration from ATP synthesis [30]

A previous systematic review also reported that administration of AOXs such as vitamin E, vitamin C, N-acetyl cysteine (NAC), carnitines, CoQ10, lycopene, selenium, and zinc, resulted in significant improvement of sperm concentration, motility, and morphology (102)

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