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FIGURE 1 3 Source and biological function of irisin Irisin, a myokine released into the circulation during exercise, was first identified by Bostrm and colleagues in 2012 (Figure 2) (Nie et al., 2020

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Phosphodiesterase-5 inhibitor, tadalafil, protects against myocardial ischemia/reperfusion through protein-kinase Gdependent generation of hydrogen sulfide