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In a dose proportionality study involving multiple CMI doses, steady-state plasma concentrations (CSS) and area-under-plasma-concentration-time curves (AUC) of CMI and CMI's major active metabolite, desmethylclomipramine (DMI), were not proportional to dose over the ranges evaluated, i.e., between 25 to 100 mg/day and between 25 to 150 mg/day, although CSS and AUC are approximately linearly related to dose between 100 to 150 mg/day

Suggested Use Take 1 capsule daily with food or as directed by your healthcare provider

Efforts were made to minimize the use of animals and alleviate pain and discomfort

Geometric least-squares mean ratios for area under the plasma concentrationtime curve from time 0 to time infinity were 1.53, 2.30, and 3.69, respectively, for mild, moderate, and severe renal impairment, versus matched participants with normal renal function