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You may be vitamin B deficient if you experience some or all of the following unexplained symptoms: Skin cracks around the mouth Scaly lip skin Skin rashes Fatigue Anemia Depression or irritability Confusion Diarrhea or constipation Abdominal cramps Tingling or numbness in your feet and hands Vitamin B12 deficiency is particularly serious, as it increases your risk for neuropsychiatric disorders