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Description

11 The anatomical linchpin is the area postrema, a small hindbrain structure that sits outside the bloodbrain barrier and is therefore directly exposed to circulating hormones

Its endogenous form has a plasma half-life of only 2-3 minutes due to rapid degradation by dipeptidyl peptidase-4 (DPP-4) and renal clearance

Learn more about Physical Medicine & Rehabilitation (PM&R) billing or credentialing services 27

According to NICE Clinical Knowledge Summaries and the British National Formulary , the standard treatment is intramuscular injections of 1,000 mcg (1 mg) hydroxocobalamin