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The X-ray spectroscopy analysis demonstrates the direct and complete binding of the Au atom of auranofin ligand to the Se atom in TXNRD [237]

Most notably, the ESCRT-III subunit charged multivesicular body protein 2B (CHMP2B) is mutated in amyotrophic lateral sclerosis and frontotemporal degeneration 11,30,31 , whereas mutations in the ESCRT-I subunit ubiquitin associated protein 1 (UBAP1) underlie hereditary spastic paraplegia (HSP) 32

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TB-500s smaller size relative to full-length T4 and its focus on the active actin-binding domain make it a research tool for studying the actin-dependent mechanisms of tissue repair promotion, for characterising PI3K/Akt-mediated cell survival and migration biology in wound healing models, and for examining the contribution of G-actin sequestration to cell motility and tissue remodelling